Simplified Deoxypropionate Acyl Chains for  Mycobacterium tuberculosis  Sulfoglycolipid Analogues: Chain Length is Essential for High Antigenicity | Zendy

Gau Benjamin | Zendy; Lemétais Aurélie | Zendy; Lepore Marco | Zendy; GarciaAlles Luis Fernando | Zendy; Bourdreux Yann | Zendy; Mori Lucia | Zendy; Gilleron Martine | Zendy; De Libero Gennaro | Zendy; Puzo Germain | Zendy; Beau JeanMarie | Zendy; Prandi Jacques | Zendy

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Simplified Deoxypropionate Acyl Chains for Mycobacterium tuberculosis Sulfoglycolipid Analogues: Chain Length is Essential for High Antigenicity

Author(s) -

Gau Benjamin,

Lemétais Aurélie,

Lepore Marco,

GarciaAlles Luis Fernando,

Bourdreux Yann,

Mori Lucia,

Gilleron Martine,

De Libero Gennaro,

Puzo Germain,

Beau JeanMarie,

Prandi Jacques

Publication year - 2013

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201300482

Subject(s) - antigenicity , mycobacterium tuberculosis , chain (unit) , computational biology , tuberculosis , chemistry , computer science , antigen , biology , combinatorial chemistry , biochemistry , genetics , medicine , physics , pathology , astronomy

The longer, the better : Increasing the lengths of the 1,3‐methyl‐branched fatty acyl chain units in mycobacterial diacylated sulfoglycolipid (Acyl 2 SGL) analogues led to dramatic improvements in their antigenic properties and gave products more potent than the natural antigen Acyl 2 SGLs.

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