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Simplified Deoxypropionate Acyl Chains for Mycobacterium tuberculosis Sulfoglycolipid Analogues: Chain Length is Essential for High Antigenicity
Author(s) -
Gau Benjamin,
Lemétais Aurélie,
Lepore Marco,
GarciaAlles Luis Fernando,
Bourdreux Yann,
Mori Lucia,
Gilleron Martine,
De Libero Gennaro,
Puzo Germain,
Beau JeanMarie,
Prandi Jacques
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300482
Subject(s) - antigenicity , mycobacterium tuberculosis , chain (unit) , computational biology , tuberculosis , chemistry , computer science , antigen , biology , combinatorial chemistry , biochemistry , genetics , medicine , physics , pathology , astronomy
The longer, the better : Increasing the lengths of the 1,3‐methyl‐branched fatty acyl chain units in mycobacterial diacylated sulfoglycolipid (Acyl 2 SGL) analogues led to dramatic improvements in their antigenic properties and gave products more potent than the natural antigen Acyl 2 SGLs.