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Biocatalytic Synthesis of Quercetin 3‐ O ‐Glucoside‐7‐ O ‐Rhamnoside by Metabolic Engineering of Escherichia coli
Author(s) -
Roepke Jonathon,
Bozzo Gale G.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300474
Subject(s) - escherichia coli , quercetin , metabolic engineering , synthetic biology , chemistry , biochemistry , world wide web , computer science , food science , computational biology , microbiology and biotechnology , biology , gene , antioxidant
You are what you eat: Quercetin 3‐ O ‐glucoside‐7‐ O ‐rhamnoside is a rare natural product with potential biological importance. We describe a strategy for the regioselective synthesis of this bisglycoside by feeding quercetin 3‐ O ‐glucoside, a naturally abundant precursor, to metabolically engineered Escherichia coli.