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Picture Perfect: DNA‐Templated Photoaffinity Labeling
Author(s) -
Barluenga Sofia,
Winssinger Nicolas
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300416
Subject(s) - nucleic acid , dna , small molecule , covalent bond , chemistry , molecule , nucleic acid thermodynamics , combinatorial chemistry , biochemistry , base sequence , organic chemistry
Just so far apart and no further: Small molecules target ID by DNA tagging. Nucleic acid hybridization has been used to pair a photo‐crosslinking group with a small molecule of interest. Following photoactivation, the protein(s) interacting with the small molecule are covalently linked to a nucleic acid tag.