Characterization of  N ‐Demethyllincosamide Methyltransferases LmbJ and CcbJ | Zendy

Najmanová Lucie | Zendy; Kutejová Eva | Zendy; Kadlec Jan | Zendy; Polan Marek | Zendy; Olšovská Jana | Zendy; Benada Oldřich | Zendy; Novotná Jitka | Zendy; Kameník Zdeněk | Zendy; Halada Petr | Zendy; Bauer Jacob | Zendy; Janata Jiří | Zendy

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Characterization of N ‐Demethyllincosamide Methyltransferases LmbJ and CcbJ

Author(s) -

Najmanová Lucie,

Kutejová Eva,

Kadlec Jan,

Polan Marek,

Olšovská Jana,

Benada Oldřich,

Novotná Jitka,

Kameník Zdeněk,

Halada Petr,

Bauer Jacob,

Janata Jiří

Publication year - 2013

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201300389

Subject(s) - methyltransferase , biosynthesis , computer science , world wide web , chemistry , library science , biochemistry , enzyme , gene , methylation

Chemical diversity : Two SAM‐dependent N ‐methyltransferases—LmbJ from the biosynthesis of the antibiotic lincomycin and CcbJ from celesticetin biosynthesis—have been characterized and compared. Both tested enzymes form multimers and are able to utilize N ‐demethyllincomycin, the natural substrate of LmbJ, with comparable efficiency.

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