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Characterization of N ‐Demethyllincosamide Methyltransferases LmbJ and CcbJ
Author(s) -
Najmanová Lucie,
Kutejová Eva,
Kadlec Jan,
Polan Marek,
Olšovská Jana,
Benada Oldřich,
Novotná Jitka,
Kameník Zdeněk,
Halada Petr,
Bauer Jacob,
Janata Jiří
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300389
Subject(s) - methyltransferase , biosynthesis , computer science , world wide web , chemistry , library science , biochemistry , enzyme , gene , methylation
Chemical diversity : Two SAM‐dependent N ‐methyltransferases—LmbJ from the biosynthesis of the antibiotic lincomycin and CcbJ from celesticetin biosynthesis—have been characterized and compared. Both tested enzymes form multimers and are able to utilize N ‐demethyllincomycin, the natural substrate of LmbJ, with comparable efficiency.