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Comparative Metabolomic Analysis of an Alternative Biosynthetic Pathway to Pseudosugars in Actinosynnema mirum DSM 43827
Author(s) -
Asamizu Shumpei,
Abugreen Mostafa,
Mahmud Taifo
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300384
Subject(s) - metabolomics , computational biology , pathway analysis , gene knockout , biology , gene , biochemistry , bioinformatics , gene expression
Through a combination of genome mining, gene knockouts, and comparative metabolomic studies, a new biosynthetic pathway to validoxylamine A has been discovered in Actinosynnema mirum DSM 43827. The study revealed the rich diversity of biosynthetic pathways to pseudosugar‐containing natural products.