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The Crosslink Formation of 2′‐OMe Oligonucleotide Containing 2‐Amino‐6‐vinylpurine Protects mRNA from miRNA‐Mediated Silencing
Author(s) -
Hagihara Shinya,
Lin WeiChen,
Kusano Shuhei,
Chao Xiaoguang,
Hori Tsuneaki,
Imoto Shuhei,
Nagatsugi Fumi
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300382
Subject(s) - gene silencing , microrna , oligonucleotide , messenger rna , computational biology , untranslated region , gene , biology , chemistry , computer science , genetics
Masking the miRNA binding site: Crosslink‐forming oligonucleotide (CFO) was used for target gene‐specific inhibition of microRNA (miRNA) functions. This method can interfere with specific miRNA–mRNA interactions by recognizing sequences unique to the 3′‐UTR that are inherent in each mRNA.