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Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G‐Quadruplexes
Author(s) -
Yangyuoru Philip M.,
Zhang Amy Y. Q.,
Shi Zhe,
Koirala Deepak,
Balasubramanian Shankar,
Mao Hanbin
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300350
Subject(s) - rna , g quadruplex , telomere , computational biology , optical tweezers , transition (genetics) , chemistry , computer science , dna , nanotechnology , biology , physics , biochemistry , gene , materials science , quantum mechanics
Potential functions: By following the unfolding and refolding of individual human RNA telomeric (TERRA) G‐quadruplexes (GQs) in laser tweezers, the mechanical stability and transition kinetics of RNA GQs are obtained. Comparison between TERRA and DNA GQs suggests their different regulatory capacities for processes associated with human telomeres.