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Small‐Molecule Procaspase Activators Identified Using Fluorescence Polarization
Author(s) -
Vickers Chris J.,
GonzálezPáez Gonzalo E.,
Umotoy Jeffrey C.,
CayananGarrett Charmagne,
Brown Steven J.,
Wolan Dennis W.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300315
Subject(s) - small molecule , chemical biology , fluorescence anisotropy , chemistry , fluorescence , drug discovery , enzyme , computational biology , biophysics , microbiology and biotechnology , biochemistry , nanotechnology , biology , materials science , physics , quantum mechanics , membrane
Wake up, protein! Small molecules that directly activate proteins are rare and their discovery opens new avenues for the development of drugs and chemical tools to probe the functions and mechanisms of protein targets. To address the one‐sided dichotomy between enzyme inhibition and activation, we describe a series of procaspase activators as chemical tools in the study of caspase biology.