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Identification of Mureidomycin Analogues and Functional Analysis of an N‐Acetyltransferase in Napsamycin Biosynthesis
Author(s) -
Tang Xiaoyu,
Gross Marcel,
Xie Yunying,
Kulik Andreas,
Gust Bertolt
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300287
Subject(s) - gene cluster , acetyltransferase , acetylation , biosynthesis , gene , biochemistry , heterologous , chemistry , peptide , n acetyltransferase , antibiotics , biology , microbiology and biotechnology
Antibiotic abundance: Several new uridyl peptide antibiotics were identified from a heterologous producer strain containing the mureidomycin/napsamycin biosynthetic gene cluster by using HRMS and LC‐ESI‐MS/MS. Analysis of the new compounds and the corresponding gene cluster revealed NpsB, an N ‐ acetyltransferase, to be responsible for acetylation of the uridyl peptide antibiotic.