Identification of Mureidomycin Analogues and Functional Analysis of an N‐Acetyltransferase in Napsamycin Biosynthesis | Zendy

Tang Xiaoyu | Zendy; Gross Marcel | Zendy; Xie Yunying | Zendy; Kulik Andreas | Zendy; Gust Bertolt | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Identification of Mureidomycin Analogues and Functional Analysis of an N‐Acetyltransferase in Napsamycin Biosynthesis

Author(s) -

Tang Xiaoyu,

Gross Marcel,

Xie Yunying,

Kulik Andreas,

Gust Bertolt

Publication year - 2013

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201300287

Subject(s) - gene cluster , acetyltransferase , acetylation , biosynthesis , gene , biochemistry , heterologous , chemistry , peptide , n acetyltransferase , antibiotics , biology , microbiology and biotechnology

Antibiotic abundance: Several new uridyl peptide antibiotics were identified from a heterologous producer strain containing the mureidomycin/napsamycin biosynthetic gene cluster by using HRMS and LC‐ESI‐MS/MS. Analysis of the new compounds and the corresponding gene cluster revealed NpsB, an N ‐ acetyltransferase, to be responsible for acetylation of the uridyl peptide antibiotic.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research