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Pulse Radiolysis Studies on the Reaction of the Reduced Vitamin B 12 Complex Cob(II)alamin with Superoxide
Author(s) -
Dassanayake Rohan S.,
Cabelli Diane E.,
Brasch Nicola E.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300229
Subject(s) - radiolysis , superoxide , chemistry , reaction rate constant , vitamin b12 , oxidative stress , computer science , biochemistry , radical , physics , kinetics , quantum mechanics , enzyme
O 2 .− scavenger: The rate constant for the rapid reaction of the ROS superoxide with the reduced vitamin B 12 radical complex cob(II)alamin was directly determined to be 3.8×10 8 M −1 s −1 . This rate was independent of pH over the range 5.5–8.7. These results have implications for studying the use of B 12 supplements to combat diseases associated with oxidative stress.