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Evidence for G‐Quadruplex DNA in Human Cells
Author(s) -
Xu Yan,
Komiyama Makoto
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300157
Subject(s) - dna , g quadruplex , binding affinities , rna , chemistry , microbiology and biotechnology , dna sequencing , biology , biochemistry , biophysics , gene , receptor
Seen in human cells: A fluorochrome‐labeled antibody probe selectively and efficiently binds all types of DNA G‐quadruplex with similar binding affinities, but hardly binds single‐ or double‐stranded DNA, or RNA hairpins. Thus, this antibody strictly discriminates between G‐quadruplex structures and other conformations of DNA and provides evidence for G‐quadruplex DNA in human cells.