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Unusual Tubulin‐Clustering Ability of Specifically C7‐Modified Colchicine Analogues
Author(s) -
Zefirova Olga N.,
Lemcke Heiko,
Lantow Margareta,
Nurieva Evgeniya V.,
Wobith Birgit,
Onishchenko Galina E.,
Hoenen Antje,
Griffiths Gareth,
Zefirov Nikolay S.,
Kuznetsov Sergei A.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300143
Subject(s) - colchicine , tubulin , microtubule , mechanism of action , chemistry , in vitro , protein subunit , mechanism (biology) , stereochemistry , microbiology and biotechnology , biophysics , biochemistry , biology , genetics , physics , quantum mechanics , gene
Highly cytotoxic C7‐modified colchicine analogues, exemplified by tubuloclustin, promote microtubule disassembly followed by the formation of very stable tubulin clusters, both in vitro and in cells. The proposed mechanism of action of tubuloclustin and its analogues, beyond that of colchicine, includes additional specific interactions with the α‐tubulin subunit.