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Recent Advances in the Study of Enzyme Promiscuity in the Tautomerase Superfamily
Author(s) -
Baas BertJan,
Zandvoort Ellen,
Geertsema Edzard M.,
Poelarends Gerrit J.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300098
Subject(s) - promiscuity , superfamily , enzyme , chemistry , biology , biochemistry , computational biology , gene , ecology
Catalytic promiscuity and evolution : Many enzymes exhibit catalytic promiscuity—the ability to catalyze reactions other than their biologically relevant one. These reactions can serve as starting points for both natural and laboratory evolution of new enzymatic functions. Recent advances in the study of enzyme promiscuity in the tautomerase superfamily are discussed.