A  Trans ‐Acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248 | Zendy

Zou Yi | Zendy; Yin Haixing | Zendy; Kong Dekun | Zendy; Deng Zixin | Zendy; Lin Shuangjun | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A Trans ‐Acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248

Author(s) -

Zou Yi,

Yin Haixing,

Kong Dekun,

Deng Zixin,

Lin Shuangjun

Publication year - 2013

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201300068

Subject(s) - polyketide , biosynthesis , stereochemistry , gene cluster , polyketide synthase , dimer , stereospecificity , chemistry , strain (injury) , trans acting , streptomyces , biochemistry , gene , biology , bacteria , genetics , organic chemistry , catalysis , mutant , anatomy

New assembly line, new compound: SIA7248, a new symmetric macrolide, was isolated from a marine‐derived Streptomyces strain. Bioinformatic analyses of the identified biosynthetic gene cluster ( sia ) for SIA7248 suggested a polyketide biosynthesis utilizing an iteratively trans ‐acting ketoreductase (KR). We characterized SiaM as a trans ‐KR to catalyse reductions of various β‐ketoacyl‐thioesters with D ‐stereospecificity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research