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Peptide Ligation–Desulfurization Chemistry at Arginine
Author(s) -
Malins Lara R.,
Cergol Katie M.,
Payne Richard J.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300049
Subject(s) - native chemical ligation , chemical ligation , ligation , chemistry , glycopeptide , peptide , arginine , combinatorial chemistry , thiol , biochemistry , chemical synthesis , amino acid , in vitro , microbiology and biotechnology , biology , antibiotics
The utility of a new β‐thiol arginine building block in ligation–desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one‐pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.