Premium
Selective Fluorogenic Chemosensors for Distinct Classes of Nucleases
Author(s) -
Jung JongWha,
Edwards Sarah K.,
Kool Eric T.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201300001
Subject(s) - nuclease , dna , computational biology , computer science , thymine , chemistry , combinatorial chemistry , nanotechnology , biochemistry , biology , materials science
Nuclease sensor trio: Fluorogenic DNA sensors were developed for distinct classes of nucleases: 3′‐exonucleases, 5′‐exonucleases, and endonucleases. The highly selective sensors, built from very small modified DNA oligomers containing the unnatural fluorescent base pyrene, and employing thymine as a quencher, were found to function in a variety of complex biological media.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom