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Inside Cover: A Pan Photoaffinity Probe for Detecting Active Forms of Matrix Metalloproteinases (ChemBioChem 1/2013)
Author(s) -
Nury Catherine,
Czarny Bertrand,
CassarLajeunesse Evelyne,
Georgiadis Dimitris,
Bregant Sarah,
Dive Vincent
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201290080
Subject(s) - matrix metalloproteinase , cover (algebra) , covalent bond , chemistry , photoaffinity labeling , proteome , combinatorial chemistry , biophysics , biochemistry , binding site , biology , organic chemistry , mechanical engineering , engineering
The inside cover picture shows the simultaneous labelling under photoirradiation of four MMP catalytic domains with a photoactivable phosphinic MMP inhibitor inside 40 mg of proteome. The specific and sensitive detection of MMP covalent complexes was achieved by radioimaging. For further details see the paper by V. Dive et al. on p. 107 ff.