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Inside Cover: Identification of the Biosynthetic Gene Cluster and Regulatory Cascade for the Synergistic Antibacterial Antibiotics Griseoviridin and Viridogrisein in Streptomyces griseoviridis (ChemBioChem 18/2012)
Author(s) -
Xie Yunchang,
Wang Bo,
Liu Jing,
Zhou Junchao,
Ma Junying,
Huang Hongbo,
Ju Jianhua
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201290075
Subject(s) - gene cluster , streptomyces , cover (algebra) , gene , computational biology , identification (biology) , antibiotics , biology , chemistry , cluster (spacecraft) , genetics , stereochemistry , combinatorial chemistry , bacteria , computer science , engineering , mechanical engineering , botany , programming language
The inside cover picture shows how expression of the griseoviridin (GV) and viridogrisein (VG) biosynthetic gene cluster in Streptomyces griseoviridis is coordinated by the SARP family positive regulators SgvT2 and SgvT3 through the γ‐butyrolactone‐like molecule and its receptor SgvB. For details, see the paper by J. Ju et al. on p. 2745 ff.