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Inside Cover: A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase (ChemBioChem 17/2012)
Author(s) -
Deng Yang,
Couch Brian A.,
Koleske Anthony J.,
Turk Benjamin E.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201290071
Subject(s) - photoaffinity labeling , peptide , tyrosine kinase , chemistry , abl , cover (algebra) , receptor tyrosine kinase , active site , stereochemistry , biochemistry , kinase , biophysics , combinatorial chemistry , binding site , biology , receptor , enzyme , mechanical engineering , engineering
The inside cover picture shows a peptide photoaffinity label modeled into the active site of the Abl tyrosine kinase. On p. 2510 ff., B. E. Turk et al. show that probes based on Abl substrates label only the active conformation of the kinase. These probes can be used to monitor Abl in complex mixtures and to decipher the mechanisms of action of small‐molecule Abl inhibitors.