Premium
Inside Cover: Fluorescent Aplyronine A: Intracellular Accumulation and Disassembly of Actin Cytoskeleton in Tumor Cells ChemBioChem 12/2012)
Author(s) -
Kita Masaki,
Yoneda Kozo,
Hirayama Yuichiro,
Yamagishi Kota,
Saito Yuki,
Sugiyama Yuka,
Miwa Yoshihiro,
Ohno Osamu,
Morita Maho,
Suenaga Kiyotake,
Kigoshi Hideo
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201290049
Subject(s) - cytoplasm , cytoskeleton , actin , actin cytoskeleton , intracellular , microbiology and biotechnology , green fluorescent protein , fluorescence , chemistry , tumor cells , biology , cell , biochemistry , gene , cancer research , physics , quantum mechanics
The inside cover picture shows HEp‐2 cells (expressing GFP‐tagged cytoplasmic actin) treated with the fluorescent derivative of aplyronine A (ApAFL, bottom). ApA is an antitumor and apoptogenic macrolide of marine origin. M. Kita, H. Kigoshi, et al. (see article on p. 1754 ff. ) have established that ApA accumulates throughout the cytoplasm and causes the rapid disassembly of the actin cytoskeleton in tumor cells.