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Cover Picture: Novel Indanone Derivatives as Potential Imaging Probes for β‐Amyloid Plaques in the Brain (ChemBioChem 11/2012)
Author(s) -
Qiao JinPing,
Gan ChangSheng,
Wang ChenWei,
Ge JinFang,
Nan DouDou,
Pan Jian,
Zhou JiangNing
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201290043
Subject(s) - senile plaques , amyloid (mycology) , chemistry , amyloid β , biodistribution , alzheimer's disease , pathology , pittsburgh compound b , biophysics , neuroscience , medicine , in vitro , biochemistry , disease , biology
The cover picture shows fluorescent microscope images (green) of amyloid plaques stained by indanone derivatives that were designed from donepezil. Using molecular imaging probes to detect senile plaques might help the early diagnosis of Alzheimer's disease (AD). On p. 1652 ff., J.‐N. Zhou et al. describe how they synthesized and characterized a novel series of indanone derivatives. The in vitro binding studies, staining of Alzheimer's disease (AD) brain sections, autoradiography, and biodistribution data all suggested that these derivatives might represent potential amyloid imaging agents for the detection of senile plaques in AD.