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Cover Picture: A New Concept for Glycosyltransferase Inhibitors: Nonionic Mimics of the Nucleotide Donor of the Human Blood Group B Galactosyltransferase (ChemBioChem 3/2012)
Author(s) -
Schaefer Katrin,
Albers Joachim,
Sindhuwinata Nora,
Peters Thomas,
Meyer Bernd
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201290004
Subject(s) - glycosyltransferase , galactosyltransferase , golgi apparatus , chemistry , stereochemistry , enzyme , nucleotide , conjugate , biochemistry , gene , mathematical analysis , mathematics , cell
The cover picture shows the human blood group B galactosyltransferase that resides in the Golgi apparatus. Design and synthesis of inhibitors of glycosyltransferases is still challenging. Here, the binding site of the enzyme is occupied by a pentityl conjugate of uric acid. Structure‐based design and synthesis led to nonionic UDP mimics that act as enzyme inhibitors. For more information, see the Full Paper by B. Meyer et al. on p. 443 ff. The illustration of the Golgi apparatus is taken from U. Lüttge, M. Kluge, G. Thiel, Botanik–Die umfassende Biologie der Pflanzen , Wiley‐VCH, Weinheim, 2010.