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The Impact of Structure on Oxidatively Generated DNA Damage Products Resulting from the C3′‐Thymidinyl Radical
Author(s) -
Amato Nicholas J.,
BryantFriedrich Amanda C.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200723
Subject(s) - oligomer , dna , chemistry , computer science , stereoselectivity , computational biology , combinatorial chemistry , information retrieval , stereochemistry , biochemistry , biology , organic chemistry , catalysis
What's the damage? Trapping the C3′‐thymidinyl radical in biologically significant architectures delivers both the repaired oligomer and 1‐(2′‐deoxy‐β‐ D ‐ threo ‐pentofuranosyl)thymidine‐containing substrates. The stereoselectivity of the reduction was found to be dependent upon the DNA structure.