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Identification and Characterization of Bacterial Diterpene Cyclases that Synthesize the Cembrane Skeleton
Author(s) -
Meguro Ayuko,
Tomita Takeo,
Nishiyama Makoto,
Kuzuyama Tomohisa
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200651
Subject(s) - diterpene , terpene , identification (biology) , biology , skeleton (computer programming) , chemistry , computational biology , biochemistry , botany , anatomy
Digging up skeletons: We report the identification and the functional characterization of two terpene cyclases (DtcycA and DtcycB) that were mined from the genome of Streptomyces sp. SANK 60404. DtcycA and DtcycB are novel bacterial diterpene cyclases for the synthesis of the cembrane skeleton.