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Flexibility and Reactivity in Promiscuous Enzymes
Author(s) -
GattiLafranconi Pietro,
Hollfelder Florian
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200628
Subject(s) - reactivity (psychology) , flexibility (engineering) , enzyme , active site , chemistry , enzyme catalysis , mechanism (biology) , combinatorial chemistry , biochemistry , computational biology , stereochemistry , biology , medicine , statistics , alternative medicine , mathematics , philosophy , epistemology , pathology
Best of both worlds: The interplay of active site reactivity and the dynamic character of proteins allows enzymes to be promiscuous and—sometimes—remarkably efficient at the same time. This review analyses the roles structural flexibility and chemical reactivity play in the catalytic mechanism of selected enzymes.