Premium
Fine Tuning the Inhibition Profile of Cyclosporine A by Derivatization of the MeBmt Residue
Author(s) -
Prell Erik,
Kahlert Viktoria,
Rücknagel Karl Peter,
Malešević Miroslav,
Fischer Gunter
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200621
Subject(s) - derivatization , residue (chemistry) , chemistry , chromatography , combinatorial chemistry , organic chemistry , mass spectrometry
Unique respect: The biological properties of four CsA derivatives were fine‐tuned by tractable modifications of the MeBmt residue. The new CsA derivatives share strong inhibitory activity toward cyclophilins (Cyps), but each is unique with respect to immunosuppressive action and cellular localization. These CsA analogues can be used to study the physiological roles of extracellular Cyps.