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Enhanced Nonenzymatic Ligation of Homopurine Miniduplexes: Support for Greater Base Stacking in a Pre‐RNA World
Author(s) -
Kuruvilla Elizabeth,
Schuster Gary B.,
Hud Nicholas V.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200601
Subject(s) - nucleic acid , nucleobase , rna , stacking , chemistry , purine , ligation , dna , base pair , base (topology) , combinatorial chemistry , biochemistry , biology , organic chemistry , microbiology and biotechnology , enzyme , gene , mathematical analysis , mathematics
The ancestors of RNA? There is a long‐standing proposal that contemporary nucleic acids might have evolved from RNA‐like polymers that utilized only purine–purine base pairs. Here we demonstrate the great advantage that increased nucleobase stacking area provides for nonenzymatic ligation.