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A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase
Author(s) -
Deng Yang,
Couch Brian A.,
Koleske Anthony J.,
Turk Benjamin E.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200560
Subject(s) - photoaffinity labeling , tyrosine kinase , peptide , kinase , chemistry , computational biology , receptor tyrosine kinase , biochemistry , abl , computer science , biology , binding site , receptor
An Abl label: The design of sensors to monitor the activity state of specific protein kinases is challenging due to the complexity of eukaryotic kinomes. Here we describe a peptide‐based photoaffinity probe that specifically labels the active conformation of the Abl tyrosine kinase.