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Comparison of Splicing Factor 3b Inhibitors in Human Cells
Author(s) -
Gao Yang,
Vogt Andreas,
Forsyth Craig J.,
Koide Kazunori
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200558
Subject(s) - rna splicing , splicing factor , spliceosome , protein subunit , alternative splicing , splice , chemistry , protein splicing , microbiology and biotechnology , computational biology , biochemistry , biology , rna , gene , exon
Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell‐based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.