Premium
Comparison of Splicing Factor 3b Inhibitors in Human Cells
Author(s) -
Gao Yang,
Vogt Andreas,
Forsyth Craig J.,
Koide Kazunori
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200558
Subject(s) - rna splicing , splicing factor , spliceosome , protein subunit , alternative splicing , splice , chemistry , protein splicing , microbiology and biotechnology , computational biology , biochemistry , biology , rna , gene , exon
Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell‐based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom