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Predicting the Structure of Cyclic Lipopeptides by Bioinformatics: Structure Revision of Arthrofactin
Author(s) -
Lange Anna,
Sun Han,
Pilger Jens,
Reinscheid Uwe M.,
Gross Harald
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200532
Subject(s) - lipopeptide , computational biology , cyclic peptide , chemistry , sequence (biology) , stereochemistry , biology , biochemistry , peptide , genetics , bacteria
Arthrofactin, a bioactive cyclic lipopeptide from Pseudomonas sp. MIS38, was reinvestigated for its structural and stereochemical features due to discrepancies between the genetics‐based sequence prediction and the currently suggested structure. The structure of arthrofactin and its derivatives was reassigned on the basis of chiral HPLC analysis and extensive NMR and MS experiments. Furthermore, derivatives of arthrofactin were discovered.