Premium
A Fluorescence‐Based Assay for p38α Recruitment Site Binders: Identification of Rooperol as a Novel p38α Kinase Inhibitor
Author(s) -
Li Jing,
Kaoud Tamer S.,
LeVieux Jake,
Gilbreath Brad,
Moharana Swapna,
Dalby Kevin N.,
Kerwin Sean M.
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200529
Subject(s) - computer science , identification (biology) , click chemistry , computational biology , field (mathematics) , chemistry , natural product , combinatorial chemistry , nanotechnology , world wide web , information retrieval , biochemistry , biology , materials science , botany , mathematics , pure mathematics
A new p38α inhibitor: Using a D ‐recruitment site (DRS) probe for p38α which exploits covalent interaction with Cys119 and alkyne–azide “click” chemistry to identify small molecules that recognize the p38α DRS, the anti‐inflammatory natural product rooperol was identified as a novel p38α inhibitor.