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A Shared Biosynthetic Pathway for Botcinins and Botrylactones Revealed through Gene Deletions
Author(s) -
Massaroli Michelli,
Moraga Javier,
Bastos Borges Keyller,
RamírezFernández Jacinto,
Viaud Muriel,
González Collado Isidro,
DuránPatrón Rosa,
HernándezGalán Rosario
Publication year - 2013
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200487
Subject(s) - polyketide , biosynthesis , botrytis cinerea , gene , mutant , biology , biochemistry , genetics , botany
Isotopic labelling experiments and the study of mutants with disrupted genes encoding botcinic acid have revealed a common link in the biosynthesis of the polyketide toxins excreted by Botrytis cinerea : botcinins and botrylactones. Furthermore, the results reported here shed light on the origin of the starter unit, thereby solving a long‐standing mystery in the biosynthesis of botcinins.