A Shared Biosynthetic Pathway for Botcinins and Botrylactones Revealed through Gene Deletions | Zendy

Massaroli Michelli | Zendy; Moraga Javier | Zendy; Bastos Borges Keyller | Zendy; RamírezFernández Jacinto | Zendy; Viaud Muriel | Zendy; González Collado Isidro | Zendy; DuránPatrón Rosa | Zendy; HernándezGalán Rosario | Zendy

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A Shared Biosynthetic Pathway for Botcinins and Botrylactones Revealed through Gene Deletions

Author(s) -

Massaroli Michelli,

Moraga Javier,

Bastos Borges Keyller,

RamírezFernández Jacinto,

Viaud Muriel,

González Collado Isidro,

DuránPatrón Rosa,

HernándezGalán Rosario

Publication year - 2013

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201200487

Subject(s) - polyketide , biosynthesis , botrytis cinerea , gene , mutant , biology , biochemistry , genetics , botany

Isotopic labelling experiments and the study of mutants with disrupted genes encoding botcinic acid have revealed a common link in the biosynthesis of the polyketide toxins excreted by Botrytis cinerea : botcinins and botrylactones. Furthermore, the results reported here shed light on the origin of the starter unit, thereby solving a long‐standing mystery in the biosynthesis of botcinins.

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