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Direct Observation of Internalization and ROS Generation of Amyloid β‐Peptide in Neuronal Cells at Subcellular Resolution
Author(s) -
Jiao Yong,
Zhang Yi,
Wei Yibin,
Liu Zhiwei,
An Wenting,
Guo Maolin
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200465
Subject(s) - internalization , endocytosis , endosome , microbiology and biotechnology , mitochondrion , reactive oxygen species , amyloid (mycology) , chemistry , confocal microscopy , peptide , biology , biochemistry , cell , intracellular , inorganic chemistry
Seeing in many colors: Confocal images acquired using fluorescently labeled amyloid β‐peptide revealed its efficient internalization by endocytosis into endosomes/lysosomes of human neuronal cells with a small portion reaching mitochondria, inducing marked cellular and mitochondrial reactive oxygen species production.