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A Chemically Programmed Antibody Is a Long‐Lasting and Potent Inhibitor of Influenza Neuraminidase
Author(s) -
Hayakawa Masahiko,
Toda Narihiro,
Carrillo Nancy,
Thornburg Natalie J.,
Crowe James E.,
Barbas Carlos F.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200439
Subject(s) - zanamivir , neuraminidase , neuraminidase inhibitor , antibody , virology , chemistry , immunology , pharmacology , medicine , virus , covid-19 , disease , infectious disease (medical specialty)
Programming an anti‐flu strategy: A new and potent neuraminidase inhibitor that maintains long‐term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.