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Rates of Fatty Acid Oxidations by P450 Compound I are pH Dependent
Author(s) -
Su Zhi,
Horner John H.,
Newcomb Martin
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200387
Subject(s) - chemistry , cytochrome p450 , heme , enzyme , catalysis , stereochemistry , hydrogen peroxide , medicinal chemistry , organic chemistry
The rates of oxidation of fatty acids by CYP119 compound I were dependent on the pH of the medium. The plot shows log k values for reactions of acids as a function of pH, where the slopes indicate mixed third‐order and fourth‐order dependence on base concentration. For palmitic acid, the rate increased 50‐fold over the pH range 6.8–7.3.