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Fluorescent Aplyronine A: Intracellular Accumulation and Disassembly of Actin Cytoskeleton in Tumor Cells
Author(s) -
Kita Masaki,
Yoneda Kozo,
Hirayama Yuichiro,
Yamagishi Kota,
Saito Yuki,
Sugiyama Yuka,
Miwa Yoshihiro,
Ohno Osamu,
Morita Maho,
Suenaga Kiyotake,
Kigoshi Hideo
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200385
Subject(s) - intracellular , cytoskeleton , actin , fluorescence , microbiology and biotechnology , chemistry , actin cytoskeleton , biophysics , biochemistry , biology , cell , physics , quantum mechanics
Nonstick : Aplyronine A (ApA) is an antitumor and apoptogenic macrolide of marine origin. We prepared a fluorescent derivative of ApA that accumulated strongly throughout the cytoplasm and caused the rapid disassembly of the actin cytoskeleton in tumor cells. We also established that ApA caused malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis.