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Genetically Targetable and Color‐Switching Fluorescent Probe
Author(s) -
Yushchenko Dmytro A.,
Zhang Ming,
Yan Qi,
Waggoner Alan S.,
Bruchez Marcel P.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200334
Subject(s) - fluorescence , chemistry , computational biology , computer science , biophysics , nanotechnology , biology , materials science , physics , optics
Color bind: We have developed a probe TMR‐ para ‐MG that switches its fluorescence emission upon binding to a fluorogen‐activating protein (FAP). In cells that express FAP, this dye labels target sites in one color and mitochondria in another color, thus it might be a suitable tool for monitoring changes in mitochondrial membrane potential.