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Crystal Structure of a Template‐Assembled Synthetic G‐Quadruplex
Author(s) -
Nikan Mehran,
Patrick Brian O.,
Sherman John C.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200262
Subject(s) - g quadruplex , template , chemistry , computer science , information retrieval , nanotechnology , computational biology , biology , materials science , dna , programming language , biochemistry
Growing interest in the structure of G‐quartets is hampered by the problem of polymorphism. Use of a template to secure the guanines into an organized array can circumvent this problem. We report the first crystal structure of a template‐assembled G‐quartet. The structure is comparable to those of natural G‐quartets, but it also shows quartet–quartet interactions where there is no covalent linkage between the quartets.