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Thioether Crosslinkages Created by a Radical SAM Enzyme
Author(s) -
Zhang Qi,
Yu Yi
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200196
Subject(s) - thioether , chemistry , lantibiotics , enzyme , sulfur , biosynthesis , stereochemistry , biochemistry , combinatorial chemistry , organic chemistry , nisin , antimicrobial
Unusually versatile: While the β‐carbon thioether linkage in lantibiotics has long been appreciated and is relatively well characterized, a recent publication shows that the unusual sulfur‐to‐α‐carbon thioether crosslinks in subtilosin A are produced by a radical SAM enzyme, AlbA, that contains two [4 Fe4 S] clusters, thus highlighting the versatility of post‐translational modifications in natural product biosynthesis.
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