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Identification of a Key Prenyltransferase Involved in Biosynthesis of the Most Abundant Fungal Meroterpenoids Derived from 3,5‐Dimethylorsellinic Acid.
Author(s) -
Itoh Takayuki,
Tokunaga Kinya,
Radhakrishnan Edayileveettil K.,
Fujii Isao,
Abe Ikuro,
Ebizuka Yutaka,
Kushiro Tetsuo
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200124
Subject(s) - prenyltransferase , biosynthesis , prenylation , chemistry , stereochemistry , ring (chemistry) , terpene , biochemistry , enzyme , organic chemistry
Destroying aromaticity: A novel prenyltransferase (Trt2) involved in fungal meroterpenoid biosynthesis was shown to catalyze an unusual aromatic addition reaction onto a fully substituted aromatic ring. The prenylated product serves as a key intermediate in the biosynthesis of the most abundant series of meroterpenoids in fungi.