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Covalent Tagging of Phosphorylated Peptides by Phosphate‐Specific Deoxyribozymes
Author(s) -
Sachdeva Amit,
Chandra Madhavaiah,
Chandrasekar Jagadeeswaran,
Silverman Scott K.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200048
Subject(s) - deoxyribozyme , phosphopeptide , chemistry , serine , phosphorylation , peptide , covalent bond , biochemistry , combinatorial chemistry , tyrosine , rna , dna , computational biology , biology , organic chemistry , gene
Hold your P's: Phosphorylated tyrosine and serine residues in peptides have been modified selectively by DNA catalysts (see graphic). These deoxyribozymes catalyze covalent attachment of an RNA tag to a range of peptide sequences, thus a proof of principle for a new approach to phosphopeptide analysis is established.