Premium
Covalent Tagging of Phosphorylated Peptides by Phosphate‐Specific Deoxyribozymes
Author(s) -
Sachdeva Amit,
Chandra Madhavaiah,
Chandrasekar Jagadeeswaran,
Silverman Scott K.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200048
Subject(s) - deoxyribozyme , phosphopeptide , chemistry , serine , phosphorylation , peptide , covalent bond , biochemistry , combinatorial chemistry , tyrosine , rna , dna , computational biology , biology , organic chemistry , gene
Hold your P's: Phosphorylated tyrosine and serine residues in peptides have been modified selectively by DNA catalysts (see graphic). These deoxyribozymes catalyze covalent attachment of an RNA tag to a range of peptide sequences, thus a proof of principle for a new approach to phosphopeptide analysis is established.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom