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Use of a Multicomponent Reaction for Chemoselective Derivatization of Multiple Classes of Metabolites
Author(s) -
Totaro Kyle A.,
Okandeji Babajide O.,
Sello Jason K.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200035
Subject(s) - derivatization , chemistry , chemoselectivity , reaction conditions , chromophore , combinatorial chemistry , organic chemistry , chromatography , high performance liquid chromatography , catalysis
We demonstrate that the Ugi reaction enables chemoselective derivatization of biological amines, carboxylic acids, aldehydes, or ketones with a chromophore under one set of reaction conditions, even in the presence of water. Derivatization of neurotransmitters, hormones, disease biomarkers and other metabolites bodes well for systems biology and diagnostic medicine.