Premium
Answers to the Carbon–Phosphorus Lyase Conundrum
Author(s) -
Zhang Qi,
van der Donk Wilfred A.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200020
Subject(s) - library science , chemistry , computer science
Organophosphonates are widespread in nature, and their catabolic pathways are of great importance for many microorganisms. In a remarkable series of biochemical experiments, Raushel and co‐workers reconstituted the carbon–phosphorus lyase activity, which cleaves the CP bond of 5‐phospho‐α‐ D ‐ribosyl‐methylphosphonate to produce methane and a cyclic phosphodiester in a reaction that requires S‐adenosylmethionine and a [4Fe–4S] cluster.