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A Caged Ligand for a Telomeric G‐Quadruplex
Author(s) -
Nakamura Takahiro,
Iida Keisuke,
Tera Masayuki,
Shinya Kazuo,
Seimiya Hiroyuki,
Nagasawa Kazuo
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201200013
Subject(s) - telomere , telomerase , g quadruplex , dna , chemistry , cancer cell , small molecule , microbiology and biotechnology , ligand (biochemistry) , biochemistry , biophysics , biology , gene , cancer , genetics , receptor
Photoactivated telomerase inhibition: The biological activities of caged compounds are masked by photolabile protecting groups, and can be unmasked with spatiotemporal specificity by light. We describe the design and synthesis of a caged G‐quadruplex (G4) ligand. On in situ activation by UV light irradiation the compound showed significant G4‐stabilizing activity and telomerase‐inhibitory activity.