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Inside Cover: Autoproteolytic Fragments Are Intermediates in the Oligomerization/Aggregation of the Parkinson's Disease Protein Alpha‐Synuclein as Revealed by Ion Mobility Mass Spectrometry (ChemBioChem 18/2011)
Author(s) -
Vlad Camelia,
Lindner Kathrin,
Karreman Christiaan,
Schildknecht Stefan,
Leist Marcel,
Tomczyk Nick,
Rontree John,
Langridge James,
Danzer Karin,
Ciossek Thomas,
Petre Alina,
Gross Michael L.,
Hengerer Bastian,
Przybylski Michael
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201190086
Subject(s) - chemistry , mass spectrometry , ion mobility spectrometry , cover (algebra) , alpha synuclein , biophysics , biochemistry , parkinson's disease , chromatography , disease , biology , mechanical engineering , medicine , engineering , pathology
The inside cover picture shows the first molecular identification of autoproteolytic fragments of the Parkinson's disease protein α‐synuclein, in particular, the highly aggregation‐prone fragment (72–140). On p. 2740 ff, M. Przybylski et al. explain how the gas‐phase separation capability of ion‐mobility mass spectrometry allowed these fragments to be identified.