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Cover Picture: Long‐Chain Lipids Are Required for the Innate Immune Recognition of Trehalose Diesters by Macrophages (ChemBioChem 17/2011)
Author(s) -
Khan Ashna A.,
Chee Stephanie H.,
McLaughlin Rene J.,
Harper Jacquie L.,
Kamena Faustin,
Timmer Mattie S. M.,
Stocker Bridget L.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201190080
Subject(s) - trehalose , innate immune system , cover (algebra) , chemistry , immune system , chain (unit) , biochemistry , biology , immunology , mechanical engineering , engineering , physics , astronomy
The cover picture shows the differential activation of macrophages by synthetic trehalose diesters of various chain lengths. Small‐chain analogues (C 4 –C 10 ) show no activity and medium‐length analogues (C 18 ) show moderate activity; however, longer derivatives (C 20 –C 26 ) lead to optimal activation of macrophages, as evidenced by NO production and the generation of cytokines such as IL‐6 and IL‐1β. For more details, see the paper by M. S. M. Timmer, B. L. Stocker et al. on p. 2572 ff.