Inside Cover: Identification of Anchor Points for Chemical Modification of a Small Cysteine‐Rich Protein by Using a Cysteine Scan (ChemBioChem 16/2011) | Zendy

Vinther Tine N. | Zendy; Ribel Ulla | Zendy; Åskov Pedersen Thomas | Zendy; Kjeldsen Thomas B. | Zendy; Jensen Knud J. | Zendy; Hubálek František | Zendy

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Inside Cover: Identification of Anchor Points for Chemical Modification of a Small Cysteine‐Rich Protein by Using a Cysteine Scan (ChemBioChem 16/2011)

Author(s) -

Vinther Tine N.,

Ribel Ulla,

Åskov Pedersen Thomas,

Kjeldsen Thomas B.,

Jensen Knud J.,

Hubálek František

Publication year - 2011

Publication title -

chembiochem

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201190075

Subject(s) - cysteine , mutagenesis , cover (algebra) , yeast , chemistry , alkylation , biochemistry , combinatorial chemistry , mutation , enzyme , gene , mechanical engineering , engineering , catalysis

The inside cover picture shows the cysteine scanning mutagenesis of insulin in yeast resulting in expression of post‐translationally modified insulin analogues. On p. 2448 ff , F. Hubálek et al. show how selective reduction and subsequent alkylation of the introduced cysteine residues allow for chemoselective modification of insulin, as illustrated by a PEGylated insulin variant.

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