Premium
Inside Cover: Identification of Anchor Points for Chemical Modification of a Small Cysteine‐Rich Protein by Using a Cysteine Scan (ChemBioChem 16/2011)
Author(s) -
Vinther Tine N.,
Ribel Ulla,
Åskov Pedersen Thomas,
Kjeldsen Thomas B.,
Jensen Knud J.,
Hubálek František
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201190075
Subject(s) - cysteine , mutagenesis , cover (algebra) , yeast , chemistry , alkylation , biochemistry , combinatorial chemistry , mutation , enzyme , gene , mechanical engineering , engineering , catalysis
The inside cover picture shows the cysteine scanning mutagenesis of insulin in yeast resulting in expression of post‐translationally modified insulin analogues. On p. 2448 ff , F. Hubálek et al. show how selective reduction and subsequent alkylation of the introduced cysteine residues allow for chemoselective modification of insulin, as illustrated by a PEGylated insulin variant.