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Inside Cover: Mutant Malonyl‐CoA Synthetases with Altered Specificity for Polyketide Synthase Extender Unit Generation (ChemBioChem 15/2011)
Author(s) -
Koryakina Irina,
Williams Gavin J.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201190070
Subject(s) - polyketide synthase , polyketide , mutant , extender , chemistry , mutagenesis , biochemistry , saturated mutagenesis , stereochemistry , substrate (aquarium) , biology , biosynthesis , enzyme , gene , organic chemistry , ecology , polyurethane
The inside cover picture shows the shift in substrate specificity of malonyl‐CoA synthetase towards non‐native malonate analogues afforded by active‐site saturation mutagenesis followed by colorimetric screening for improved activity. Mutant synthetases could provide extender units for probing the activity of polyketide synthases. For further details, see the paper by G. J. Williams and I. Koryakina on p. 2289 ff.