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Insight into the Rescue of Oxidized Soluble Guanylate Cyclase by the Activator Cinaciguat
Author(s) -
Surmeli Nur Basak,
Marletta Michael A.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100809
Subject(s) - guanylate cyclase , gucy1a3 , nitric oxide , activator (genetics) , heme , gucy1b3 , chemistry , soluble guanylyl cyclase , guanylate cyclase 2c , biochemistry , dysfunctional family , gucy2d , receptor , microbiology and biotechnology , pharmacology , enzyme , biology , medicine , clinical psychology , organic chemistry
Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme.