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A FlAsH Reporter for Protein‐Dimerization Triggers
Author(s) -
Stafforst Thorsten
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100787
Subject(s) - flash (photography) , nanotechnology , computational biology , chemistry , chemical biology , biophysics , aggregation induced emission , combinatorial chemistry , microbiology and biotechnology , biochemistry , biology , materials science , physics , fluorescence , quantum mechanics , optics
A FlAsH of potential: The specific binding of the biarsenical probe to the tetracysteine motif has matured as a tool for cell biology studies. Combining two such binders in one probe generates a useful reporter of protein dimerization events. The current state of art and the perspective for future developments are highlighted.